Priveel Custom Peptides- Peptidomimetics

Peptidomimetics

At Priveel Custom Peptides we bridge the gap between natural biology and small-molecule drug discovery. Our mission is to empower biopharmaceutical innovators and academic researchers globally by transforming vulnerable, short-lived peptide sequences into stable, bioavailable, and translationally viable peptidomimetics.

WHY CHOOSE PEPTIDOMIMETICS ?

Property	Natural Peptides	Our Custom Peptidomimetics
Metabolic Stability	Low (Rapidly degraded by proteases within minutes)	High (Resists enzymatic cleavage via engineered backbones)
Membrane Permeability	Poor (Difficult cellular uptake)	Enhanced (Modified side chains improve lipophilicity)
Target Affinity	High but flexible (Loss of entropy)	Locked & Rigid (Macrocyclized for precise binding)
In Vivo Half-Life	Short (Requires frequent dosing)	Extended (Optimized pharmacokinetic profiles)

What We do in Peptidomimetics

PHASE 1: TARGET CHARACTERIZATION

• Identify Native Lead Sequence & Binding Affinity
• Resolve Bioactive Conformation (NMR / X-ray)
• Map Critical Residues via Alanine Scanning
• Next Step: Proceed to Rational Design.

PHASE 2: RATIONAL DESIGN

• Backbone Mimicry (Amide Bond Bioisosteres, Peptoids)
• Non-Natural Side Chains (D-Amino Acids, Bulky Groups)
• Macrocyclization (Disulfide Staples, Hydrocarbon Stapling)
• Next Step: Proceed to Synthesis & ScreeningLength of the peptide from 20aa to 200aa.

PHASE 3: SYNTHESIS & SCREENING

• Solid-Phase Peptide Synthesis (SPPS) & RP-HPLC Purification
• Proteolytic Stability Assays (Serum/Plasma Half-Life)
• Binding Kinematics Evaluation (SPR, BLI, or ITC for Kd)
• Next Step: Proceed to Optimization & In Vivo.

PHASE 4: OPTIMIZATION & IN VIVO

• Permeability Testing (PAMPA or Caco-2 Monolayers)
• In Silico Refinement & Docking to Minimize Toxicity
• Preclinical In Vivo Pharmacokinetics (PK/PD Modeling)

Peptidomimetics

What We do in Peptidomimetics

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